Assay Detail
Functional
CHEMBL4401048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of recombinant human APJ expressed in rat Chem5 cells co-expressing Galpha15 by Calcium 6-QF dye based fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.97 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3234446 | — | — | 1 | 8.72 |
| CHEMBL4472749 | — | — | 1 | 8.60 |
| CHEMBL4550078 | — | — | 1 | 8.59 |
| CHEMBL4098390 | — | — | 1 | 8.39 |
| CHEMBL4065973 | — | — | 1 | 8.31 |
| CHEMBL4464954 | — | — | 1 | 8.20 |
| CHEMBL4440817 | — | — | 1 | 7.95 |
| CHEMBL4439951 | — | — | 1 | 6.75 |
| CHEMBL4559795 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3234446 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4472749 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4550078 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4098390 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4065973 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4464954 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4440817 | — | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL4439951 | — | EC50 | = | 176.0 | nM | 6.75 |
| CHEMBL4559795 | — | EC50 | = | 568.0 | nM | 6.25 |