Assay Detail
Functional
CHEMBL4401222
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Antiproliferative activity against human T47D cells after 24 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based drug design, synthesis, In vitro, and In vivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-α inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.38 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590512 | — | — | 1 | 4.55 |
| CHEMBL4539135 | — | — | 1 | 4.48 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.46 |
| CHEMBL4570601 | — | — | 1 | 4.46 |
| CHEMBL4435453 | — | — | 1 | 4.45 |
| CHEMBL4571261 | — | — | 1 | 4.40 |
| CHEMBL4444460 | — | — | 1 | 4.35 |
| CHEMBL4553545 | — | — | 1 | 4.34 |
| CHEMBL4555331 | — | — | 1 | 4.29 |
| CHEMBL4516755 | — | — | 1 | 4.24 |
| CHEMBL4468912 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590512 | — | IC50 | = | 28230.0 | nM | 4.55 |
| CHEMBL4539135 | — | IC50 | = | 32960.0 | nM | 4.48 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 34420.0 | nM | 4.46 |
| CHEMBL4570601 | — | IC50 | = | 35060.0 | nM | 4.46 |
| CHEMBL4435453 | — | IC50 | = | 35750.0 | nM | 4.45 |
| CHEMBL4571261 | — | IC50 | = | 40060.0 | nM | 4.40 |
| CHEMBL4444460 | — | IC50 | = | 45040.0 | nM | 4.35 |
| CHEMBL4553545 | — | IC50 | = | 46160.0 | nM | 4.34 |
| CHEMBL4555331 | — | IC50 | = | 51340.0 | nM | 4.29 |
| CHEMBL4516755 | — | IC50 | = | 57130.0 | nM | 4.24 |
| CHEMBL4468912 | — | IC50 | = | 63740.0 | nM | 4.20 |