Assay Detail
Binding
CHEMBL4401976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant G6A iPLA2 using arachidonyl-1-14C PAPC and PAPC incubated for 30 mins by HPLC-MS analysis based radioactivity-based group specific mixed micelle assay
14
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
85/88 kDa calcium-independent phospholipase A2 (CHEMBL3213) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
β-Lactones: A Novel Class of Ca<sup>2+</sup>-Independent Phospholipase A<sub>2</sub> (Group VIA iPLA<sub>2</sub>) Inhibitors with the Ability To Inhibit β-Cell Apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| XI50 | 12 | - | - |
| IC50 | 2 | 7.23 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476476 | — | — | 2 | 9.00 |
| CHEMBL4439384 | — | — | 2 | 5.46 |
| CHEMBL1095003 | — | — | 1 | - |
| CHEMBL3818906 | — | — | 1 | - |
| CHEMBL4543220 | — | — | 1 | - |
| CHEMBL4440328 | — | — | 1 | - |
| CHEMBL4581494 | — | — | 1 | - |
| CHEMBL4462080 | — | — | 1 | - |
| CHEMBL4530817 | — | — | 1 | - |
| CHEMBL4460099 | — | — | 1 | - |
| CHEMBL2420367 | — | — | 1 | - |
| CHEMBL460312 | FKGK11 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476476 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4439384 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1095003 | — | XI50 | = | 0.0002 | mole fraction | - |
| CHEMBL3818906 | — | XI50 | = | 0.0057 | mole fraction | - |
| CHEMBL4543220 | — | XI50 | = | 0.00019 | mole fraction | - |
| CHEMBL4440328 | — | XI50 | = | 0.0003 | mole fraction | - |
| CHEMBL4581494 | — | XI50 | = | 0.00019 | mole fraction | - |
| CHEMBL4462080 | — | XI50 | = | 0.038 | mole fraction | - |
| CHEMBL4530817 | — | XI50 | = | 9e-05 | mole fraction | - |
| CHEMBL4460099 | — | XI50 | = | 0.0021 | mole fraction | - |
| CHEMBL2420367 | — | XI50 | = | 0.0001 | mole fraction | - |
| CHEMBL460312 | FKGK11 | XI50 | = | 0.0014 | mole fraction | - |
| CHEMBL4439384 | — | XI50 | = | 0.007 | mole fraction | - |
| CHEMBL4476476 | — | XI50 | = | 2.1e-05 | mole fraction | - |