Assay Detail
Functional
CHEMBL4402289
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In vivo antagonist activity at HPGDS in po dosed C57BL/6J mouse assessed as inhibition of compound 48/80-induced PGD2 release into peritoneal lavage fluid pretreated for 1 hr followed by compound 48/80 addition and measured after 7 mins by EIA
3
Total Activities
1
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.68 | 7.68 |
| ED50 | 1 | - | - |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473072 | — | — | 3 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473072 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4473072 | — | ED50 | = | 0.032 | mg.kg-1 | - |
| CHEMBL4473072 | — | Inhibition | - | % | - |