Assay Detail
Binding
CHEMBL4407501
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Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.47 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26915 | SC-560 | — | 1 | 8.00 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.38 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 5.21 |
| CHEMBL704 | MESALAMINE | 4.0 | 1 | 5.11 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 4.73 |
| CHEMBL4448450 | — | — | 1 | 4.41 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL42485 | DUP-697 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26915 | SC-560 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL25 | ASPIRIN | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL704 | MESALAMINE | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 18790.0 | nM | 4.73 |
| CHEMBL4448450 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL118 | CELECOXIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL42485 | DUP-697 | IC50 | > | 3000.0 | nM | - |