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Assay Detail

CHEMBL4407610

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-parasitic activity against Trypanosoma cruzi
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones.
da Silva Júnior EN, Jardim GAM, Jacob C, Dhawa U, Ackermann L, de Castro SL.
Eur J Med Chem (2019) 179 : 863 -915
PubMed 31306817 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.54 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4173823 1 6.72
CHEMBL4165449 1 6.30
CHEMBL4160933 1 6.22
CHEMBL4162297 1 6.00
CHEMBL4161242 1 5.92
CHEMBL4177178 1 5.91
CHEMBL4175198 1 5.85
CHEMBL4168732 1 5.80
CHEMBL4163114 1 5.66
CHEMBL4166557 1 5.22
CHEMBL3952951 1 4.26
CHEMBL3974809 1 4.06
CHEMBL3908949 1 4.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4173823 IC50 = 190.0 nM 6.72
CHEMBL4165449 IC50 = 500.0 nM 6.30
CHEMBL4160933 IC50 = 600.0 nM 6.22
CHEMBL4162297 IC50 = 1000.0 nM 6.00
CHEMBL4161242 IC50 = 1200.0 nM 5.92
CHEMBL4177178 IC50 = 1240.0 nM 5.91
CHEMBL4175198 IC50 = 1400.0 nM 5.85
CHEMBL4168732 IC50 = 1600.0 nM 5.80
CHEMBL4163114 IC50 = 2200.0 nM 5.66
CHEMBL4166557 IC50 = 6030.0 nM 5.22
CHEMBL3952951 IC50 = 55300.0 nM 4.26
CHEMBL3974809 IC50 = 86700.0 nM 4.06
CHEMBL3908949 IC50 = 89500.0 nM 4.05