Assay Detail
Binding
CHEMBL4408523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured for 1 min by DTNB reagent-based spectrophotometric analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.29 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4462677 | — | — | 1 | 6.09 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.03 |
| CHEMBL4518306 | — | — | 1 | 6.02 |
| CHEMBL4536953 | — | — | 1 | 5.96 |
| CHEMBL4569192 | — | — | 1 | 5.87 |
| CHEMBL4453853 | — | — | 1 | 5.82 |
| CHEMBL4545023 | — | — | 1 | 5.64 |
| CHEMBL4442490 | — | — | 1 | 5.57 |
| CHEMBL4473288 | — | — | 1 | 5.53 |
| CHEMBL4557653 | — | — | 1 | 5.51 |
| CHEMBL4522175 | — | — | 1 | 5.48 |
| CHEMBL4476086 | — | — | 1 | 5.41 |
| CHEMBL4474948 | — | — | 1 | 5.34 |
| CHEMBL4574930 | — | — | 1 | 5.31 |
| CHEMBL4566824 | — | — | 1 | 5.29 |
| CHEMBL4450353 | — | — | 1 | 5.26 |
| CHEMBL4589809 | — | — | 1 | 5.22 |
| CHEMBL4588952 | — | — | 1 | 5.21 |
| CHEMBL4442752 | — | — | 1 | 5.20 |
| CHEMBL4474675 | — | — | 1 | 5.19 |
| CHEMBL4451956 | — | — | 1 | 5.17 |
| CHEMBL4515408 | — | — | 1 | 5.13 |
| CHEMBL4472865 | — | — | 1 | 5.13 |
| CHEMBL4435341 | — | — | 1 | 5.08 |
| CHEMBL4575964 | — | — | 1 | 5.06 |
| CHEMBL4450342 | — | — | 1 | 5.04 |
| CHEMBL4565910 | — | — | 1 | 4.96 |
| CHEMBL4457720 | — | — | 1 | 4.95 |
| CHEMBL4439615 | — | — | 1 | 4.93 |
| CHEMBL4439886 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4462677 | — | IC50 | = | 817.0 | nM | 6.09 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 941.0 | nM | 6.03 |
| CHEMBL4518306 | — | IC50 | = | 957.0 | nM | 6.02 |
| CHEMBL4536953 | — | IC50 | = | 1085.0 | nM | 5.96 |
| CHEMBL4569192 | — | IC50 | = | 1365.0 | nM | 5.87 |
| CHEMBL4453853 | — | IC50 | = | 1517.0 | nM | 5.82 |
| CHEMBL4545023 | — | IC50 | = | 2272.0 | nM | 5.64 |
| CHEMBL4442490 | — | IC50 | = | 2676.0 | nM | 5.57 |
| CHEMBL4473288 | — | IC50 | = | 2972.0 | nM | 5.53 |
| CHEMBL4557653 | — | IC50 | = | 3112.0 | nM | 5.51 |
| CHEMBL4522175 | — | IC50 | = | 3317.0 | nM | 5.48 |
| CHEMBL4476086 | — | IC50 | = | 3852.0 | nM | 5.41 |
| CHEMBL4474948 | — | IC50 | = | 4562.0 | nM | 5.34 |
| CHEMBL4574930 | — | IC50 | = | 4856.0 | nM | 5.31 |
| CHEMBL4566824 | — | IC50 | = | 5186.0 | nM | 5.29 |
| CHEMBL4450353 | — | IC50 | = | 5539.0 | nM | 5.26 |
| CHEMBL4589809 | — | IC50 | = | 6052.0 | nM | 5.22 |
| CHEMBL4588952 | — | IC50 | = | 6193.0 | nM | 5.21 |
| CHEMBL4442752 | — | IC50 | = | 6327.0 | nM | 5.20 |
| CHEMBL4474675 | — | IC50 | = | 6476.0 | nM | 5.19 |
| CHEMBL4451956 | — | IC50 | = | 6757.0 | nM | 5.17 |
| CHEMBL4515408 | — | IC50 | = | 7379.0 | nM | 5.13 |
| CHEMBL4472865 | — | IC50 | = | 7327.0 | nM | 5.13 |
| CHEMBL4435341 | — | IC50 | = | 8392.0 | nM | 5.08 |
| CHEMBL4575964 | — | IC50 | = | 8762.0 | nM | 5.06 |
| CHEMBL4450342 | — | IC50 | = | 9012.0 | nM | 5.04 |
| CHEMBL4565910 | — | IC50 | = | 11102.0 | nM | 4.96 |
| CHEMBL4457720 | — | IC50 | = | 11274.0 | nM | 4.95 |
| CHEMBL4439615 | — | IC50 | = | 11736.0 | nM | 4.93 |
| CHEMBL4439886 | — | IC50 | = | 12971.0 | nM | 4.89 |
| CHEMBL4529285 | — | IC50 | = | 15126.0 | nM | 4.82 |
| CHEMBL4437417 | — | IC50 | = | 16763.0 | nM | 4.78 |
| CHEMBL4463270 | — | IC50 | = | 24212.0 | nM | 4.62 |
| CHEMBL4558783 | — | IC50 | = | 32296.0 | nM | 4.49 |