Assay Detail
Binding
CHEMBL4408647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DAMGO from full length human MOR expressed in chem5 cells incubated for 60 mins by liquid scintillation counter
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.88 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.22 |
| CHEMBL4457304 | — | — | 1 | 7.77 |
| CHEMBL4438974 | — | — | 1 | 7.54 |
| CHEMBL4536869 | — | — | 1 | 7.14 |
| CHEMBL4476530 | — | — | 1 | 7.12 |
| CHEMBL4448866 | — | — | 1 | 6.98 |
| CHEMBL4471708 | — | — | 1 | 6.86 |
| CHEMBL4459611 | — | — | 1 | 6.78 |
| CHEMBL4453980 | — | — | 1 | 6.75 |
| CHEMBL4442473 | — | — | 1 | 6.69 |
| CHEMBL4457595 | — | — | 1 | 6.65 |
| CHEMBL4562769 | — | — | 1 | 6.62 |
| CHEMBL4555508 | — | — | 1 | 6.62 |
| CHEMBL4438643 | — | — | 1 | 6.58 |
| CHEMBL4571845 | — | — | 1 | 6.49 |
| CHEMBL4483060 | — | — | 1 | 6.43 |
| CHEMBL4586277 | — | — | 1 | 6.37 |
| CHEMBL4553702 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 6.08 | nM | 8.22 |
| CHEMBL4457304 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4438974 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4536869 | — | Ki | = | 72.4 | nM | 7.14 |
| CHEMBL4476530 | — | Ki | = | 76.2 | nM | 7.12 |
| CHEMBL4448866 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL4471708 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL4459611 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL4453980 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL4442473 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL4457595 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL4562769 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4555508 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4438643 | — | Ki | = | 261.0 | nM | 6.58 |
| CHEMBL4571845 | — | Ki | = | 322.0 | nM | 6.49 |
| CHEMBL4483060 | — | Ki | = | 368.0 | nM | 6.43 |
| CHEMBL4586277 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL4553702 | — | Ki | = | 507.0 | nM | 6.29 |