Assay Detail
Binding
CHEMBL4409275
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Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation counting
10
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress in the development of more effective and safer analgesics for pain management.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.62 | 8.84 |
| Ki | 4 | 10.96 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4550234 | — | — | 2 | 10.96 |
| CHEMBL4521879 | — | — | 2 | 10.96 |
| CHEMBL4439415 | — | — | 2 | 10.96 |
| CHEMBL4450250 | — | — | 2 | 10.96 |
| CHEMBL4577301 | — | — | 1 | 8.84 |
| CHEMBL4544686 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4550234 | — | Ki | = | 0.0109 | nM | 10.96 |
| CHEMBL4521879 | — | Ki | = | 0.0109 | nM | 10.96 |
| CHEMBL4439415 | — | Ki | = | 0.0109 | nM | 10.96 |
| CHEMBL4450250 | — | Ki | = | 0.0109 | nM | 10.96 |
| CHEMBL4577301 | — | EC50 | = | 1.45 | nM | 8.84 |
| CHEMBL4544686 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4550234 | — | EC50 | = | 0.00177 | nM | - |
| CHEMBL4521879 | — | EC50 | = | 0.00177 | nM | - |
| CHEMBL4439415 | — | EC50 | = | 0.00177 | nM | - |
| CHEMBL4450250 | — | EC50 | = | 0.00177 | nM | - |