Assay Detail
Functional
CHEMBL4409282
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Inhibition of mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated for 30 mins followed by forskolin-stimulation and measured after 60 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress in the development of more effective and safer analgesics for pain management.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.06 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4467777 | — | — | 1 | 7.28 |
| CHEMBL4533745 | — | — | 1 | 7.28 |
| CHEMBL4577586 | — | — | 1 | 7.28 |
| CHEMBL4581231 | — | — | 1 | 7.28 |
| CHEMBL4456635 | — | — | 1 | 7.28 |
| CHEMBL4530626 | — | — | 1 | 6.69 |
| CHEMBL4462475 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4467777 | — | EC50 | = | 52.41 | nM | 7.28 |
| CHEMBL4533745 | — | EC50 | = | 52.41 | nM | 7.28 |
| CHEMBL4577586 | — | EC50 | = | 52.41 | nM | 7.28 |
| CHEMBL4581231 | — | EC50 | = | 52.41 | nM | 7.28 |
| CHEMBL4456635 | — | EC50 | = | 52.41 | nM | 7.28 |
| CHEMBL4530626 | — | EC50 | = | 203.4 | nM | 6.69 |
| CHEMBL4462475 | — | EC50 | = | 455.6 | nM | 6.34 |