Assay Detail
Binding
CHEMBL4409664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.41 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.30 |
| CHEMBL4457939 | — | — | 1 | 9.04 |
| CHEMBL4476294 | — | — | 1 | 8.96 |
| CHEMBL4544153 | — | — | 1 | 8.89 |
| CHEMBL4438415 | — | — | 1 | 8.57 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.54 |
| CHEMBL4543789 | — | — | 1 | 8.52 |
| CHEMBL4471208 | — | — | 1 | 8.40 |
| CHEMBL4441488 | — | — | 1 | 8.15 |
| CHEMBL4434876 | — | — | 1 | 7.85 |
| CHEMBL4539622 | — | — | 1 | 7.85 |
| CHEMBL4459410 | — | — | 1 | 7.68 |
| CHEMBL4574299 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4457939 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4476294 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4544153 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4438415 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2104993 | VORTIOXETINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4543789 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4471208 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4441488 | — | IC50 | = | 7.08 | nM | 8.15 |
| CHEMBL4434876 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4539622 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4459410 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4574299 | — | IC50 | = | 23.0 | nM | 7.64 |