Assay Detail
Binding
CHEMBL4409804
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Inhibition of porcine liver carboxylesterase using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.12 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564380 | — | — | 1 | 7.16 |
| CHEMBL4585339 | — | — | 1 | 6.49 |
| CHEMBL4475685 | — | — | 1 | 6.20 |
| CHEMBL1231178 | — | — | 1 | 5.75 |
| CHEMBL4438172 | — | — | 1 | 5.58 |
| CHEMBL4461638 | — | — | 1 | 5.56 |
| CHEMBL153 | TROLOX | — | 1 | - |
| CHEMBL196 | ASCORBIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564380 | — | IC50 | = | 69.6 | nM | 7.16 |
| CHEMBL4585339 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL4475685 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1231178 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4438172 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL4461638 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL153 | TROLOX | IC50 | - | — | - | |
| CHEMBL196 | ASCORBIC ACID | IC50 | - | — | - |