Assay Detail
Binding
CHEMBL4410698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and antidepressant-like activity of novel alkoxy-piperidine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.45 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.54 |
| CHEMBL4472767 | — | — | 1 | 7.07 |
| CHEMBL4444213 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2104993 | VORTIOXETINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4472767 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4444213 | — | IC50 | = | 177.0 | nM | 6.75 |