Assay Detail
Functional
CHEMBL4410833
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Antiproliferative activity against human A2780 cells incubated for 72 hrs by CellTiterGlo assay
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.72 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4558559 | — | — | 1 | 9.70 |
| CHEMBL4438525 | — | — | 1 | 9.40 |
| CHEMBL4536277 | — | — | 1 | 9.22 |
| CHEMBL4450629 | — | — | 1 | 9.15 |
| CHEMBL4446132 | — | — | 1 | 9.05 |
| CHEMBL4483695 | — | — | 1 | 8.82 |
| CHEMBL4448916 | — | — | 1 | 8.64 |
| CHEMBL4546918 | — | — | 1 | 8.30 |
| CHEMBL4456070 | — | — | 1 | 8.24 |
| CHEMBL4556614 | — | — | 1 | 8.23 |
| CHEMBL4561577 | — | — | 1 | 8.12 |
| CHEMBL4457730 | — | — | 1 | 7.96 |
| CHEMBL4586676 | — | — | 1 | 7.77 |
| CHEMBL4451769 | — | — | 1 | 7.60 |
| CHEMBL4205098 | — | — | 1 | 7.57 |
| CHEMBL4439536 | — | — | 1 | 7.47 |
| CHEMBL4532502 | — | — | 1 | 7.44 |
| CHEMBL4469631 | — | — | 1 | 7.35 |
| CHEMBL4441045 | — | — | 1 | 7.34 |
| CHEMBL4571655 | — | — | 1 | 7.24 |
| CHEMBL4575553 | — | — | 1 | 7.17 |
| CHEMBL4213004 | — | — | 1 | 7.00 |
| CHEMBL4444464 | — | — | 1 | 6.62 |
| CHEMBL4552727 | — | — | 1 | 6.47 |
| CHEMBL4540185 | — | — | 1 | 6.30 |
| CHEMBL4541056 | — | — | 1 | 6.11 |
| CHEMBL4561390 | — | — | 1 | 5.99 |
| CHEMBL4446579 | — | — | 2 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4558559 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4438525 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4536277 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4450629 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4446132 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4483695 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4448916 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4546918 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4456070 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4556614 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4561577 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4457730 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4586676 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4451769 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4205098 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4439536 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4532502 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4469631 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4441045 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4571655 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4575553 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4213004 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4444464 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4552727 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4540185 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4541056 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4561390 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4446579 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4446579 | — | IC50 | > | 2500.0 | nM | - |