Assay Detail
ADMET
CHEMBL4410836
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Inhibition of human recombinant CYP3A4 using midazolam as substrate incubated for 40 to 130 mins in presence of NADPH by LC-MS/MS analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.45 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4483695 | — | — | 1 | 5.52 |
| CHEMBL4448916 | — | — | 1 | 5.51 |
| CHEMBL4469631 | — | — | 1 | 5.33 |
| CHEMBL4439536 | — | — | 1 | - |
| CHEMBL4540185 | — | — | 1 | - |
| CHEMBL4552727 | — | — | 1 | - |
| CHEMBL4444464 | — | — | 1 | - |
| CHEMBL4571655 | — | — | 1 | - |
| CHEMBL4457730 | — | — | 1 | - |
| CHEMBL4441045 | — | — | 1 | - |
| CHEMBL4541056 | — | — | 1 | - |
| CHEMBL4561577 | — | — | 1 | - |
| CHEMBL4556614 | — | — | 1 | - |
| CHEMBL4451769 | — | — | 1 | - |
| CHEMBL4456070 | — | — | 1 | - |
| CHEMBL4586676 | — | — | 1 | - |
| CHEMBL4532502 | — | — | 1 | - |
| CHEMBL4575553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4483695 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4448916 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL4469631 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL4439536 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4540185 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4552727 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4444464 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4571655 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4457730 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4441045 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4541056 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4561577 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4556614 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4451769 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4456070 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4586676 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4532502 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4575553 | — | IC50 | > | 25000.0 | nM | - |