Assay Detail
Binding
CHEMBL4411356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human tyrosinase
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of Melanogenesis: An Updated Review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.22 | 5.94 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | — | 1 | 5.94 |
| CHEMBL48310 | HINOKITIOL | — | 1 | 5.05 |
| CHEMBL450195 | RUCINOL | — | 1 | 4.68 |
| CHEMBL3898657 | — | — | 1 | - |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL537 | HYDROQUINONE | 4.0 | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL48310 | HINOKITIOL | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL450195 | RUCINOL | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3898657 | — | Ki | = | 128000.0 | nM | - |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 500000.0 | nM | - |
| CHEMBL537 | HYDROQUINONE | IC50 | = | 4400000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 6500000.0 | nM | - |