Assay Detail
Functional
CHEMBL4411736
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Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by Alamar blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.31 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.89 |
| CHEMBL4568385 | — | — | 1 | 5.35 |
| CHEMBL4470863 | — | — | 1 | 5.19 |
| CHEMBL4435569 | — | — | 1 | 5.16 |
| CHEMBL2152494 | EMPETRIKARINOL B | — | 1 | 5.00 |
| CHEMBL3331100 | — | — | 1 | 4.91 |
| CHEMBL4444309 | — | — | 1 | 4.82 |
| CHEMBL524326 | — | — | 1 | 4.79 |
| CHEMBL121305 | DELTA-TOCOTRIENOL | — | 1 | 4.71 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
| CHEMBL4466886 | — | — | 1 | - |
| CHEMBL4448769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4568385 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4470863 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4435569 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2152494 | EMPETRIKARINOL B | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3331100 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4444309 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL524326 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL121305 | DELTA-TOCOTRIENOL | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL269671 | ARTEMISININ | IC50 | - | — | - | |
| CHEMBL4466886 | — | IC50 | - | — | - | |
| CHEMBL4448769 | — | IC50 | - | — | - |