Assay Detail
Functional
CHEMBL4415908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticonvulsant activity in po dosed SCN8A N1768D mutant harboring C57BL/6J/C3HeB/FeJ mouse model of 6Hz electroshock-induced seizure assessed as plasma concentration causing 50% reduction in seizure frequency pretreated for 2 hrs followed by 6 Hz electrical stimulation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na<sub>V</sub>1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.56 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435054 | — | — | 1 | 7.22 |
| CHEMBL4471825 | — | — | 1 | 6.33 |
| CHEMBL4460028 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435054 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4471825 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4460028 | — | EC50 | = | 720.0 | nM | 6.14 |