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Assay Detail

CHEMBL4416963

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human 697 cells after 48 hrs by CellTiter 96 aqueous one solution assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type 697
Confidence 1 — Organism
Curated By Autocuration

Target

697 (CHEMBL2366253)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
Vergani B, Sandrone G, Marchini M, Ripamonti C, Cellupica E, Galbiati E, Caprini G, Pavich G, Porro G, Rocchio I, Lattanzio M, Pezzuto M, Skorupska M, Cordella P, Pagani P, Pozzi P, Pomarico R, Modena D, Leoni F, Perego R, Fossati G, Steinkühler C, Stevenazzi A.
J Med Chem (2019) 62 : 10711 -10739
PubMed 31710483 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.06 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1213492 GIVINOSTAT 4.0 1 7.00
CHEMBL2364628 RICOLINOSTAT 2.0 1 6.70
CHEMBL2179618 NEXTURASTAT A 1 6.40
CHEMBL2018302 TUBASTATIN A 1 5.70
CHEMBL3655950 1 5.47
CHEMBL4066043 1 5.08
CHEMBL4434656 1 -
CHEMBL4537736 1 -
CHEMBL4453121 1 -
CHEMBL4440341 1 -
CHEMBL4470373 1 -
CHEMBL4568509 1 -
CHEMBL4461219 1 -
CHEMBL4448410 1 -
CHEMBL4445138 1 -
CHEMBL4458053 1 -
CHEMBL4515782 1 -
CHEMBL4516856 1 -
CHEMBL4470302 1 -
CHEMBL4583522 1 -
CHEMBL4556171 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1213492 GIVINOSTAT IC50 = 100.0 nM 7.00
CHEMBL2364628 RICOLINOSTAT IC50 = 201.0 nM 6.70
CHEMBL2179618 NEXTURASTAT A IC50 = 401.0 nM 6.40
CHEMBL2018302 TUBASTATIN A IC50 = 2006.0 nM 5.70
CHEMBL3655950 IC50 = 3390.0 nM 5.47
CHEMBL4066043 IC50 = 8330.0 nM 5.08
CHEMBL4434656 IC50 > 10000.0 nM -
CHEMBL4537736 IC50 > 1000.0 nM -
CHEMBL4453121 IC50 > 1000.0 nM -
CHEMBL4440341 IC50 > 1000.0 nM -
CHEMBL4470373 IC50 > 1000.0 nM -
CHEMBL4568509 IC50 > 1000.0 nM -
CHEMBL4461219 IC50 > 1000.0 nM -
CHEMBL4448410 IC50 > 1000.0 nM -
CHEMBL4445138 IC50 > 1000.0 nM -
CHEMBL4458053 IC50 > 1000.0 nM -
CHEMBL4515782 IC50 > 1000.0 nM -
CHEMBL4516856 IC50 > 1000.0 nM -
CHEMBL4470302 IC50 > 1000.0 nM -
CHEMBL4583522 IC50 > 1000.0 nM -
CHEMBL4556171 IC50 > 1000.0 nM -