Assay Detail
Binding
CHEMBL4418809
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Inhibition of Myc (unknown origin) expressed in HEK293T cells incubated for 16 hrs by firefly/renilla luciferase reporter gene assay
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Myc modulators and uses thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 5.50 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587215 | — | — | 1 | 6.58 |
| CHEMBL4587175 | — | — | 1 | 6.44 |
| CHEMBL4463878 | — | — | 1 | 6.40 |
| CHEMBL4436752 | — | — | 1 | 6.36 |
| CHEMBL4439086 | — | — | 1 | 6.27 |
| CHEMBL4462590 | — | — | 1 | 6.20 |
| CHEMBL4571888 | — | — | 1 | 6.19 |
| CHEMBL4472238 | — | — | 1 | 6.19 |
| CHEMBL4546151 | — | — | 1 | 6.17 |
| CHEMBL4441910 | — | — | 1 | 6.10 |
| CHEMBL4459178 | — | — | 1 | 6.08 |
| CHEMBL4457623 | — | — | 1 | 6.03 |
| CHEMBL4573749 | — | — | 1 | 6.01 |
| CHEMBL4463755 | — | — | 1 | 6.00 |
| CHEMBL4592867 | — | — | 1 | 5.98 |
| CHEMBL4435169 | — | — | 1 | 5.92 |
| CHEMBL4532086 | — | — | 1 | 5.91 |
| CHEMBL4574226 | — | — | 1 | 5.83 |
| CHEMBL4473046 | — | — | 1 | 5.82 |
| CHEMBL4562187 | — | — | 1 | 5.79 |
| CHEMBL4578105 | — | — | 1 | 5.79 |
| CHEMBL4574806 | — | — | 1 | 5.78 |
| CHEMBL4573018 | — | — | 1 | 5.74 |
| CHEMBL4473626 | — | — | 1 | 5.71 |
| CHEMBL4454353 | — | — | 1 | 5.65 |
| CHEMBL4448869 | — | — | 1 | 5.64 |
| CHEMBL4475974 | — | — | 1 | 5.56 |
| CHEMBL4514011 | — | — | 1 | 5.49 |
| CHEMBL4566803 | — | — | 1 | 5.48 |
| CHEMBL4543327 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587215 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4587175 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4463878 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4436752 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4439086 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4462590 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4571888 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4472238 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4546151 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4441910 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4459178 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4457623 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4573749 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4463755 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4592867 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4435169 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4532086 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4574226 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4473046 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4562187 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4578105 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4574806 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4573018 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4473626 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4454353 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4448869 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4475974 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4514011 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL4566803 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4543327 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL4518596 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL4437143 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4448611 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL4442536 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL4515903 | — | IC50 | = | 6770.0 | nM | 5.17 |
| CHEMBL4440863 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL4574522 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4450452 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL4454546 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4564939 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL4591315 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL4461881 | — | IC50 | = | 10230.0 | nM | 4.99 |
| CHEMBL4524189 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4447869 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4591604 | — | IC50 | = | 26810.0 | nM | 4.57 |
| CHEMBL4435325 | — | IC50 | = | 29970.0 | nM | 4.52 |
| CHEMBL4445261 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL4438510 | — | IC50 | = | 33650.0 | nM | 4.47 |
| CHEMBL4571287 | — | IC50 | = | 57470.0 | nM | 4.24 |
| CHEMBL4587371 | — | IC50 | = | 59370.0 | nM | 4.23 |