Assay Detail
Binding
CHEMBL4418865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 4.95 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099818 | — | — | 1 | 6.24 |
| CHEMBL4064112 | — | — | 1 | 6.21 |
| CHEMBL4076203 | — | — | 1 | 6.16 |
| CHEMBL4062382 | — | — | 1 | 6.00 |
| CHEMBL4071732 | — | — | 1 | 5.96 |
| CHEMBL4454422 | — | — | 1 | 5.54 |
| CHEMBL4069646 | — | — | 1 | 5.48 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 5.40 |
| CHEMBL4467946 | — | — | 1 | 5.36 |
| CHEMBL4076383 | — | — | 1 | 5.26 |
| CHEMBL4060974 | — | — | 1 | 5.23 |
| CHEMBL4285561 | — | — | 1 | 5.17 |
| CHEMBL4277321 | — | — | 1 | 5.15 |
| CHEMBL4279510 | — | — | 1 | 5.14 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 5.11 |
| CHEMBL4089157 | — | — | 1 | 5.09 |
| CHEMBL4084911 | — | — | 1 | 5.06 |
| CHEMBL4080360 | — | — | 1 | 5.03 |
| CHEMBL4288490 | — | — | 1 | 4.82 |
| CHEMBL4454277 | — | — | 1 | 4.82 |
| CHEMBL4096864 | — | — | 1 | 4.77 |
| CHEMBL4081811 | — | — | 1 | 4.70 |
| CHEMBL4277615 | — | — | 1 | 4.51 |
| CHEMBL4287431 | — | — | 1 | 4.51 |
| CHEMBL1289198 | — | — | 1 | 4.47 |
| CHEMBL4290845 | — | — | 1 | 4.46 |
| CHEMBL4286541 | — | — | 1 | 4.41 |
| CHEMBL4292800 | — | — | 1 | 4.34 |
| CHEMBL4294661 | — | — | 1 | 4.27 |
| CHEMBL4277834 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099818 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4064112 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4076203 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4062382 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4071732 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4454422 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4069646 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4467946 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4076383 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4060974 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4285561 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4277321 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4279510 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4089157 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4084911 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4080360 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4288490 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4454277 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4096864 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4081811 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4277615 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4287431 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1289198 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4290845 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4286541 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4292800 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4294661 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4277834 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4280607 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1289650 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4294428 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL4291251 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL4281100 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4100761 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4073992 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3558288 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4286830 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL4279593 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4294730 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4291325 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4283482 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4290253 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4283057 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4293651 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4076483 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4289116 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL4291991 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4277689 | — | IC50 | = | 150000.0 | nM | - |