Assay Detail
Binding
CHEMBL4420274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TFPI in human plasma with induced factor-8 deficiency assessed as increase in thrombin generation by measuring FEIBA at 10 uM using thrombin-specific fluorogenic substrate Z-Gly-Gly-Arg-AMC by calibrated automated thrombography
327
Total Activities
327
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tfpi inhibitors and methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 324 | - | - |
| EC50 | 3 | 7.79 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4546481 | — | — | 1 | 8.32 |
| CHEMBL4473203 | — | — | 1 | 8.00 |
| CHEMBL4545581 | — | — | 1 | 7.06 |
| CHEMBL4468325 | — | — | 1 | - |
| CHEMBL4464679 | — | — | 1 | - |
| CHEMBL4448683 | — | — | 1 | - |
| CHEMBL4452712 | — | — | 1 | - |
| CHEMBL4474759 | — | — | 1 | - |
| CHEMBL4441789 | — | — | 1 | - |
| CHEMBL4450866 | — | — | 1 | - |
| CHEMBL4521549 | — | — | 1 | - |
| CHEMBL4525286 | — | — | 1 | - |
| CHEMBL4438997 | — | — | 1 | - |
| CHEMBL4533244 | — | — | 1 | - |
| CHEMBL4444481 | — | — | 1 | - |
| CHEMBL3983321 | — | — | 1 | - |
| CHEMBL4441212 | — | — | 1 | - |
| CHEMBL4441617 | — | — | 1 | - |
| CHEMBL4469457 | — | — | 1 | - |
| CHEMBL4442183 | — | — | 1 | - |
| CHEMBL4437738 | — | — | 1 | - |
| CHEMBL4465308 | — | — | 1 | - |
| CHEMBL4552854 | — | — | 1 | - |
| CHEMBL4472478 | — | — | 1 | - |
| CHEMBL4450021 | — | — | 1 | - |
| CHEMBL4447278 | — | — | 1 | - |
| CHEMBL4458645 | — | — | 1 | - |
| CHEMBL4475946 | — | — | 1 | - |
| CHEMBL4439952 | — | — | 1 | - |
| CHEMBL4446430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4546481 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4473203 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4545581 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3927791 | — | Activity | = | 151.0 | mU/ml | - |
| CHEMBL3896444 | — | Activity | = | 49.0 | mU/ml | - |
| CHEMBL3919315 | — | Activity | = | 163.0 | mU/ml | - |
| CHEMBL3909443 | — | Activity | = | 156.0 | mU/ml | - |
| CHEMBL4444450 | — | Activity | = | 165.0 | mU/ml | - |
| CHEMBL3947562 | — | Activity | = | 192.0 | mU/ml | - |
| CHEMBL3979191 | — | Activity | = | 95.0 | mU/ml | - |
| CHEMBL3890567 | — | Activity | = | 62.0 | mU/ml | - |
| CHEMBL3908506 | — | Activity | = | 204.0 | mU/ml | - |
| CHEMBL3975098 | — | Activity | = | 82.0 | mU/ml | - |
| CHEMBL3948427 | — | Activity | = | 69.0 | mU/ml | - |
| CHEMBL3950569 | — | Activity | = | 86.0 | mU/ml | - |
| CHEMBL4440103 | — | Activity | = | 34.0 | mU/ml | - |
| CHEMBL3985851 | — | Activity | = | 38.0 | mU/ml | - |
| CHEMBL3898666 | — | Activity | = | 105.0 | mU/ml | - |
| CHEMBL4438102 | — | Activity | = | 100.0 | mU/ml | - |
| CHEMBL4454094 | — | Activity | = | 40.0 | mU/ml | - |
| CHEMBL3940709 | — | Activity | - | — | - | |
| CHEMBL3940379 | — | Activity | = | 133.0 | mU/ml | - |
| CHEMBL3908160 | — | Activity | = | 197.0 | mU/ml | - |
| CHEMBL3955549 | — | Activity | = | 220.0 | mU/ml | - |
| CHEMBL4482926 | — | Activity | = | 147.0 | mU/ml | - |
| CHEMBL3938403 | — | Activity | = | 79.0 | mU/ml | - |
| CHEMBL3943623 | — | Activity | = | 180.0 | mU/ml | - |
| CHEMBL4522409 | — | Activity | = | 36.0 | mU/ml | - |
| CHEMBL4474279 | — | Activity | = | 153.0 | mU/ml | - |
| CHEMBL4446952 | — | Activity | = | 331.0 | mU/ml | - |
| CHEMBL4455442 | — | Activity | = | 101.0 | mU/ml | - |
| CHEMBL4514015 | — | Activity | = | 316.0 | mU/ml | - |
| CHEMBL3958151 | — | Activity | = | 197.0 | mU/ml | - |
| CHEMBL3960826 | — | Activity | = | 188.0 | mU/ml | - |
| CHEMBL3901896 | — | Activity | = | 202.0 | mU/ml | - |
| CHEMBL3958681 | — | Activity | = | 202.0 | mU/ml | - |
| CHEMBL3939160 | — | Activity | = | 161.0 | mU/ml | - |
| CHEMBL3936395 | — | Activity | = | 161.0 | mU/ml | - |
| CHEMBL3893542 | — | Activity | = | 124.0 | mU/ml | - |
| CHEMBL3940948 | — | Activity | = | 168.0 | mU/ml | - |
| CHEMBL3953245 | — | Activity | = | 183.0 | mU/ml | - |
| CHEMBL3950581 | — | Activity | = | 191.0 | mU/ml | - |
| CHEMBL3958577 | — | Activity | = | 178.0 | mU/ml | - |
| CHEMBL3966852 | — | Activity | = | 186.0 | mU/ml | - |
| CHEMBL3954974 | — | Activity | = | 171.0 | mU/ml | - |
| CHEMBL4536290 | — | Activity | = | 178.0 | mU/ml | - |
| CHEMBL3924693 | — | Activity | = | 193.0 | mU/ml | - |
| CHEMBL3931437 | — | Activity | = | 185.0 | mU/ml | - |
| CHEMBL3934143 | — | Activity | = | 162.0 | mU/ml | - |
| CHEMBL3896235 | — | Activity | = | 169.0 | mU/ml | - |