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Assay Detail

CHEMBL4420443

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to N-terminal GST-tagged CNK PHD (unknown origin) by SPR assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Connector enhancer of kinase suppressor of ras 1 (CHEMBL4296242)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Compounds, compositions and methods for inhibiting cnksr1
(2016)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 22 4.77 6.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4293794 1 6.73
CHEMBL4283567 1 5.47
CHEMBL4288751 1 5.10
CHEMBL4278527 1 4.60
CHEMBL4293956 1 4.48
CHEMBL4282649 1 4.44
CHEMBL4285086 1 4.41
CHEMBL4280622 1 4.21
CHEMBL4278841 1 4.17
CHEMBL4277129 1 4.12
CHEMBL4278147 1 -
CHEMBL4277811 1 -
CHEMBL4294863 1 -
CHEMBL4287230 1 -
CHEMBL4283706 1 -
CHEMBL4286687 1 -
CHEMBL4442523 1 -
CHEMBL4279325 1 -
CHEMBL4280394 1 -
CHEMBL4280751 1 -
CHEMBL4282291 1 -
CHEMBL4472901 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4293794 Kd = 186.0 nM 6.73
CHEMBL4283567 Kd = 3370.0 nM 5.47
CHEMBL4288751 Kd = 7900.0 nM 5.10
CHEMBL4278527 Kd = 25000.0 nM 4.60
CHEMBL4293956 Kd = 33000.0 nM 4.48
CHEMBL4282649 Kd = 36000.0 nM 4.44
CHEMBL4285086 Kd = 39000.0 nM 4.41
CHEMBL4280622 Kd = 62000.0 nM 4.21
CHEMBL4278841 Kd = 67000.0 nM 4.17
CHEMBL4277129 Kd = 75000.0 nM 4.12
CHEMBL4278147 Kd < 50000.0 nM -
CHEMBL4277811 Kd > 100000.0 nM -
CHEMBL4294863 Kd - -
CHEMBL4287230 Kd - -
CHEMBL4283706 Kd > 100000.0 nM -
CHEMBL4286687 Kd > 100000.0 nM -
CHEMBL4442523 Kd - -
CHEMBL4279325 Kd = 123000.0 nM -
CHEMBL4280394 Kd > 500000.0 nM -
CHEMBL4280751 Kd - -
CHEMBL4282291 Kd < 50000.0 nM -
CHEMBL4472901 Kd - -