Assay Detail
Binding
CHEMBL4423151
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Inhibition of ovine COX1 using arachidonic acid as substrate by colorimetric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.01 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | 4.0 | 1 | 8.10 |
| CHEMBL4590829 | — | — | 1 | 7.38 |
| CHEMBL4462870 | — | — | 1 | 7.12 |
| CHEMBL4475349 | — | — | 1 | 7.00 |
| CHEMBL4571499 | — | — | 1 | 6.92 |
| CHEMBL4441970 | — | — | 1 | 6.46 |
| CHEMBL4470970 | — | — | 1 | 5.52 |
| CHEMBL4570802 | — | — | 1 | 5.12 |
| CHEMBL4436511 | — | — | 1 | 5.08 |
| CHEMBL4567742 | — | — | 1 | 4.92 |
| CHEMBL4449420 | — | — | 1 | 4.92 |
| CHEMBL4445036 | — | — | 1 | 4.89 |
| CHEMBL4544804 | — | — | 1 | 4.64 |
| CHEMBL4465969 | — | — | 1 | - |
| CHEMBL4515876 | — | — | 1 | - |
| CHEMBL4513580 | — | — | 1 | - |
| CHEMBL4470659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4590829 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4462870 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4475349 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4571499 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4441970 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4470970 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4570802 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4436511 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4567742 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4449420 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4445036 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4544804 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4465969 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4515876 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4513580 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4470659 | — | IC50 | > | 50000.0 | nM | - |