Assay Detail
Binding
CHEMBL4423709
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Inhibition of Tie-2 (unknown origin) after 1 hrs by ADP-Glo luminescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.97 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.41 |
| CHEMBL4539395 | — | — | 1 | 9.09 |
| CHEMBL4476000 | — | — | 1 | 8.75 |
| CHEMBL4469077 | — | — | 1 | 8.57 |
| CHEMBL4459732 | — | — | 1 | 8.26 |
| CHEMBL4437530 | — | — | 1 | 8.26 |
| CHEMBL4525897 | — | — | 1 | 8.04 |
| CHEMBL4553163 | — | — | 1 | 7.86 |
| CHEMBL4452405 | — | — | 1 | 7.59 |
| CHEMBL4472113 | — | — | 1 | 7.33 |
| CHEMBL4436670 | — | — | 1 | 7.29 |
| CHEMBL4456738 | — | — | 1 | 7.29 |
| CHEMBL4543212 | — | — | 1 | 7.11 |
| CHEMBL4448354 | — | — | 1 | 6.68 |
| CHEMBL4447942 | — | — | 1 | - |
| CHEMBL4449073 | — | — | 1 | - |
| CHEMBL4575350 | — | — | 1 | - |
| CHEMBL4470139 | — | — | 1 | - |
| CHEMBL4453627 | — | — | 1 | - |
| CHEMBL4516255 | — | — | 1 | - |
| CHEMBL4570733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL4539395 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL4476000 | — | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL4469077 | — | IC50 | = | 2.69 | nM | 8.57 |
| CHEMBL4459732 | — | IC50 | = | 5.45 | nM | 8.26 |
| CHEMBL4437530 | — | IC50 | = | 5.46 | nM | 8.26 |
| CHEMBL4525897 | — | IC50 | = | 9.11 | nM | 8.04 |
| CHEMBL4553163 | — | IC50 | = | 13.71 | nM | 7.86 |
| CHEMBL4452405 | — | IC50 | = | 25.74 | nM | 7.59 |
| CHEMBL4472113 | — | IC50 | = | 46.39 | nM | 7.33 |
| CHEMBL4436670 | — | IC50 | = | 51.44 | nM | 7.29 |
| CHEMBL4456738 | — | IC50 | = | 51.86 | nM | 7.29 |
| CHEMBL4543212 | — | IC50 | = | 77.42 | nM | 7.11 |
| CHEMBL4448354 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4447942 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4449073 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4575350 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4470139 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4453627 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4516255 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4570733 | — | IC50 | - | — | - |