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Assay Detail

CHEMBL4424484

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Algicidal activity against wild-type Synechocystis sp. PCC 6803 after 24 hrs by microbroth dilution method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Synechocystis sp. PCC 6803
Confidence 1 — Organism
Curated By Autocuration

Target

Synechocystis sp. PCC 6803 (CHEMBL4513211)
Type ORGANISM
Organism Synechocystis sp. PCC 6803

Publication

Design, synthesis and algicides activities of thiourea derivatives as the novel scaffold aldolase inhibitors.
Xiao S, Wei L, Hong Z, Rao L, Ren Y, Wan J, Feng L.
Bioorg Med Chem (2019) 27 : 805 -812
PubMed 30711311 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 6.02 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1551854 1 6.55
CHEMBL1411435 1 6.06
CHEMBL4520626 1 5.90
CHEMBL1506216 1 5.57
CHEMBL4469784 1 -
CHEMBL4566399 1 -
CHEMBL4562397 1 -
CHEMBL1424907 1 -
CHEMBL4448356 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1551854 EC50 = 280.0 nM 6.55
CHEMBL1411435 EC50 = 880.0 nM 6.06
CHEMBL4520626 EC50 = 1250.0 nM 5.90
CHEMBL1506216 EC50 = 2700.0 nM 5.57
CHEMBL4469784 EC50 = 1.58 ppm -
CHEMBL4566399 EC50 = 8.2 ppm -
CHEMBL4562397 EC50 = 5.9 ppm -
CHEMBL1424907 EC50 = 0.39 ppm -
CHEMBL4448356 EC50 = 0.98 ppm -