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Compound Detail

CHEMBL1506216

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O=C(NNC(=S)NC(=O)c1ccccc1)c1ccc([N+](=O)[O-])cc1

Basic Information

ChEMBL ID CHEMBL1506216
Phase Preclinical
Structure Type MOL
InChI Key GBSKPTZPLQAXKO-UHFFFAOYSA-N
7
Targets
7
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

344.4
MW (Da)
1.54
ALogP
5
HBA
3
HBD
113.4
PSA (Ų)
0.44
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H12N4O4S
MW 344.35
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.96

Activity Summary

EC50 6 meas. best 5.83
Ki 1 meas. best 5.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 5.83 5.83 1463.0 1
Synechocystis sp. PCC 6803
CHEMBL4513211
EC50 5.57 5.57 2700.0 1
Fructose-bisphosphate aldolase class 2
CHEMBL4523320
Ki 5.55 5.55 2800.0 1
Streptokinase A
CHEMBL1293228
EC50 5.49 5.49 3234.0 1
ATP-dependent molecular chaperone HSP82
CHEMBL1293251
EC50 5.39 5.39 4115.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.38 5.38 4217.0 1
Streptococcus
CHEMBL612313
EC50 4.81 4.81 15541.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30711311 10.1016/j.bmc.2019.01.023 Synechocystis sp. PCC 6803 1
30711311 10.1016/j.bmc.2019.01.023 Fructose-bisphosphate aldolase class 2 1

Data from ChEMBL 36 via Core Engine