Assay Detail
Binding
CHEMBL4424466
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Inhibition of recombinant Synechocystis sp. PCC 6803 FBA2 expressed in Escherichia coli BL21 (DE3) using FBP as substrate measured over 5 mins
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Synechocystis sp. PCC 6803 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Fructose-bisphosphate aldolase class 2 (CHEMBL4523320) ↗| Type | SINGLE PROTEIN |
| Organism | Synechocystis sp. (strain PCC 6803 / Kazusa) |
Publication
Design, synthesis and algicides activities of thiourea derivatives as the novel scaffold aldolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.54 | 6.20 |
| Inhibition | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448356 | — | — | 1 | 6.20 |
| CHEMBL1551854 | — | — | 1 | 6.19 |
| CHEMBL1411435 | — | — | 1 | 6.06 |
| CHEMBL4520626 | — | — | 1 | 5.90 |
| CHEMBL1424907 | — | — | 1 | 5.73 |
| CHEMBL4476697 | — | — | 1 | 5.72 |
| CHEMBL4450278 | — | — | 1 | 5.60 |
| CHEMBL1506216 | — | — | 1 | 5.55 |
| CHEMBL4562397 | — | — | 1 | 5.51 |
| CHEMBL4566399 | — | — | 1 | 5.46 |
| CHEMBL4469784 | — | — | 1 | 5.28 |
| CHEMBL4456429 | — | — | 1 | 5.26 |
| CHEMBL4455886 | — | — | 1 | 5.26 |
| CHEMBL4468799 | — | — | 1 | 5.04 |
| CHEMBL4439217 | — | — | 1 | 5.04 |
| CHEMBL4439146 | — | — | 1 | 4.78 |
| CHEMBL4449437 | — | — | 1 | - |
| CHEMBL2236348 | — | — | 1 | - |
| CHEMBL4471739 | — | — | 1 | - |
| CHEMBL4460225 | — | — | 1 | - |
| CHEMBL1525631 | — | — | 1 | - |
| CHEMBL3087543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448356 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL1551854 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL1411435 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL4520626 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL1424907 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL4476697 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4450278 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL1506216 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL4562397 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL4566399 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL4469784 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL4456429 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL4455886 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL4468799 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL4439217 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL4439146 | — | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL4449437 | — | Inhibition | = | 60.0 | % | - |
| CHEMBL2236348 | — | Inhibition | = | 42.0 | % | - |
| CHEMBL4471739 | — | Inhibition | = | 22.0 | % | - |
| CHEMBL4460225 | — | Inhibition | = | 37.0 | % | - |
| CHEMBL1525631 | — | Inhibition | = | 15.0 | % | - |
| CHEMBL3087543 | — | Inhibition | = | 30.0 | % | - |