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Target Snapshot

CHEMBL4523320 Target Snapshot

Fructose-bisphosphate aldolase class 2 · SINGLE PROTEIN · Synechocystis sp. (strain PCC 6803 / Kazusa)

22Compounds
9Assays
0Approved Drugs
32.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q55664. Use UniProt Q55664 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q55664 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fructose-bisphosphate aldolase class 2 as ChEMBL target CHEMBL4523320, mapped to UniProt Q55664. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fructose-bisphosphate aldolase class 2
SINGLE PROTEIN · Synechocystis sp. (strain PCC 6803 / Kazusa)
As of 2026-09-14
ChEMBL target ID
CHEMBL4523320
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q55664
Fructose-bisphosphate aldolase class 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fructose-bisphosphate aldolase class 2 is the right protein anchor across sources, using UniProt Q55664 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFructose-bisphosphate aldolase class 2
UniProt AccessionQ55664
Component TypeProtein
Sequence Length359 aa

Fructose-bisphosphate aldolase class 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Fructose-bisphosphate aldolase class 2, mapped to UniProt Q55664. Sequence length is 359 aa.

Mapped IDQ55664
Review nameFructose-bisphosphate aldolase class 2
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa)
Assay Mix

Activity Type Distribution

KI32.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4448356 6.2 Ki 630.0 Preclinical
CHEMBL1551854 6.19 Ki 650.0 Preclinical
CHEMBL1411435 6.06 Ki 880.0 Preclinical
CHEMBL4520626 5.9 Ki 1250.0 Preclinical
CHEMBL1424907 5.73 Ki 1870.0 Preclinical
CHEMBL4476697 5.72 Ki 1900.0 Preclinical
CHEMBL4450278 5.6 Ki 2500.0 Preclinical
CHEMBL1506216 5.55 Ki 2800.0 Preclinical
CHEMBL4562397 5.51 Ki 3100.0 Preclinical
CHEMBL4566399 5.46 Ki 3500.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
6
5.5
4
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

9
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 9 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 9 16 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine