Assay Detail
ADMET
CHEMBL4424686
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Inhibition of CYP2C9 (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.96 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459785 | — | — | 1 | 5.40 |
| CHEMBL4592312 | — | — | 1 | 5.30 |
| CHEMBL4466252 | — | — | 1 | 5.10 |
| CHEMBL4465467 | — | — | 1 | 5.10 |
| CHEMBL4457637 | — | — | 1 | 5.10 |
| CHEMBL4537290 | — | — | 1 | 5.05 |
| CHEMBL4565775 | — | — | 1 | 4.89 |
| CHEMBL4562022 | — | — | 1 | 4.82 |
| CHEMBL4526549 | — | — | 1 | 4.77 |
| CHEMBL4459391 | — | — | 1 | 4.75 |
| CHEMBL4459015 | — | — | 1 | 4.75 |
| CHEMBL4454941 | — | — | 1 | 4.75 |
| CHEMBL4439812 | — | — | 1 | 4.72 |
| CHEMBL4572081 | — | — | 1 | - |
| CHEMBL4445659 | — | — | 1 | - |
| CHEMBL4456152 | — | — | 1 | - |
| CHEMBL4437131 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459785 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4592312 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4466252 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4465467 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4457637 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4537290 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4565775 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4562022 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4526549 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4459391 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4459015 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4454941 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4439812 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4572081 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4445659 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4456152 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4437131 | — | IC50 | > | 20000.0 | nM | - |