Assay Detail
ADMET
CHEMBL4425908
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Inhibition of CYP3A4 (unknown origin)
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 10 | - | - |
| IC50 | 1 | 6.47 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571067 | — | — | 1 | 6.47 |
| CHEMBL4435650 | — | — | 1 | - |
| CHEMBL4592894 | — | — | 1 | - |
| CHEMBL4114404 | — | — | 1 | - |
| CHEMBL4460988 | — | — | 1 | - |
| CHEMBL3675721 | — | — | 1 | - |
| CHEMBL4436718 | — | — | 1 | - |
| CHEMBL4474917 | — | — | 1 | - |
| CHEMBL4565958 | — | — | 1 | - |
| CHEMBL4527526 | — | — | 1 | - |
| CHEMBL4446409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571067 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4435650 | — | Inhibition | - | % | - | |
| CHEMBL4592894 | — | Inhibition | - | % | - | |
| CHEMBL4114404 | — | Inhibition | - | % | - | |
| CHEMBL4460988 | — | Inhibition | - | % | - | |
| CHEMBL3675721 | — | Inhibition | - | % | - | |
| CHEMBL4436718 | — | Inhibition | - | % | - | |
| CHEMBL4474917 | — | Inhibition | - | % | - | |
| CHEMBL4565958 | — | Inhibition | - | % | - | |
| CHEMBL4527526 | — | Inhibition | - | % | - | |
| CHEMBL4446409 | — | Inhibition | - | % | - |