Assay Detail
Binding
CHEMBL4426404
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Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.38 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4557949 | — | — | 1 | 9.70 |
| CHEMBL4542061 | — | — | 1 | 9.70 |
| CHEMBL4447359 | — | — | 1 | 9.52 |
| CHEMBL4447575 | — | — | 1 | 9.52 |
| CHEMBL4553127 | — | — | 1 | 9.52 |
| CHEMBL4469836 | — | — | 1 | 9.52 |
| CHEMBL4567187 | — | — | 1 | 9.30 |
| CHEMBL4441872 | — | — | 1 | 9.22 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.92 |
| CHEMBL4576419 | — | — | 1 | 8.85 |
| CHEMBL4562845 | — | — | 1 | 8.48 |
| CHEMBL4559114 | — | — | 1 | 8.41 |
| CHEMBL4561437 | — | — | 1 | 8.39 |
| CHEMBL4533292 | — | — | 1 | 8.21 |
| CHEMBL4467102 | — | — | 1 | 8.16 |
| CHEMBL4593639 | — | — | 1 | 8.14 |
| CHEMBL4450368 | — | — | 1 | 8.11 |
| CHEMBL4445710 | — | — | 1 | 8.11 |
| CHEMBL4464372 | — | — | 1 | 8.06 |
| CHEMBL4569919 | — | — | 1 | 8.06 |
| CHEMBL4574280 | — | — | 1 | 7.98 |
| CHEMBL4466283 | — | — | 1 | 7.93 |
| CHEMBL4557543 | — | — | 1 | 7.85 |
| CHEMBL4571948 | — | — | 1 | 7.85 |
| CHEMBL4440491 | — | — | 1 | 7.84 |
| CHEMBL4448605 | — | — | 1 | 7.78 |
| CHEMBL4535664 | — | — | 1 | 7.37 |
| CHEMBL4527389 | — | — | 1 | 7.13 |
| CHEMBL4437058 | — | — | 1 | 5.43 |
| CHEMBL4580145 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4557949 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4542061 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4447359 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4447575 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4553127 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4469836 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4567187 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4441872 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4576419 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4562845 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4559114 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4561437 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4533292 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4467102 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4593639 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4450368 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4445710 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4464372 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4569919 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4574280 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4466283 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL4557543 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4571948 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL4440491 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL4448605 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL4535664 | — | IC50 | = | 42.4 | nM | 7.37 |
| CHEMBL4527389 | — | IC50 | = | 74.4 | nM | 7.13 |
| CHEMBL4437058 | — | IC50 | = | 3709.0 | nM | 5.43 |
| CHEMBL4580145 | — | IC50 | > | 5000.0 | nM | - |