Compound Detail
CHEMBL4535664
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Basic Information
| ChEMBL ID | CHEMBL4535664 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QOXHLMBFXQEXNL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
443.3
MW (Da)
5.20
ALogP
5
HBA
2
HBD
89.1
PSA (Ų)
0.44
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.37 | 7.37 | 42.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 42.4 | nM | 7.37 | Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incub... | 27326339 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27326339 | 10.1021/acsmedchemlett.6b00066 | Fibroblast growth factor receptor 1 | 1 |
| 27326339 | 10.1021/acsmedchemlett.6b00066 | NCI-H1581 | 1 |
Data from ChEMBL 36 via Core Engine