Assay Detail
ADMET
CHEMBL4426445
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Inhibition of CYP3A4 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.62 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3654680 | — | — | 1 | 6.42 |
| CHEMBL3654682 | — | — | 1 | 6.11 |
| CHEMBL2408789 | — | — | 1 | 5.41 |
| CHEMBL3663084 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3654680 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3654682 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL2408789 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3663084 | — | IC50 | = | 29000.0 | nM | 4.54 |