Assay Detail
ADMET
CHEMBL4427616
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Inhibition of CYP1A2 (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.61 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4526347 | — | — | 1 | 6.70 |
| CHEMBL4446613 | — | — | 1 | 6.50 |
| CHEMBL4576833 | — | — | 1 | 6.10 |
| CHEMBL4437930 | — | — | 1 | 6.00 |
| CHEMBL4474551 | — | — | 1 | 5.80 |
| CHEMBL4515962 | — | — | 1 | 5.70 |
| CHEMBL4470706 | — | — | 1 | 5.20 |
| CHEMBL4569690 | — | — | 1 | 5.10 |
| CHEMBL4513488 | — | — | 1 | 4.70 |
| CHEMBL4564126 | TP-008 | — | 1 | 4.30 |
| CHEMBL4443611 | — | — | 1 | - |
| CHEMBL4483492 | — | — | 1 | - |
| CHEMBL4452818 | — | — | 1 | - |
| CHEMBL4467267 | — | — | 1 | - |
| CHEMBL4572312 | — | — | 1 | - |
| CHEMBL4470980 | — | — | 1 | - |
| CHEMBL4468495 | — | — | 1 | - |
| CHEMBL4555703 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4526347 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4446613 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4576833 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4437930 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4474551 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4515962 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4470706 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4569690 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4513488 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4564126 | TP-008 | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL4443611 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4483492 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4452818 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4467267 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4572312 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4470980 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4468495 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4555703 | — | IC50 | > | 50118.72 | nM | - |