Assay Detail
Functional
CHEMBL4427762
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Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FL5.12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.35 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322333 | DIMETHYLSPINGOSINE | — | 1 | 6.10 |
| CHEMBL4467146 | — | — | 1 | 5.92 |
| CHEMBL4549134 | — | — | 1 | 5.85 |
| CHEMBL4439872 | — | — | 1 | 5.77 |
| CHEMBL4440140 | — | — | 1 | 5.77 |
| CHEMBL4438374 | — | — | 1 | 5.72 |
| CHEMBL4554223 | — | — | 1 | 5.72 |
| CHEMBL2441554 | — | — | 1 | 5.70 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.62 |
| CHEMBL4520668 | — | — | 1 | 5.62 |
| CHEMBL4529441 | — | — | 1 | 5.62 |
| CHEMBL4579003 | — | — | 1 | 5.60 |
| CHEMBL4517011 | — | — | 1 | 5.58 |
| CHEMBL4548392 | — | — | 1 | 5.57 |
| CHEMBL4455831 | — | — | 1 | 5.55 |
| CHEMBL2441555 | — | — | 1 | 5.52 |
| CHEMBL4533650 | — | — | 1 | 5.48 |
| CHEMBL448741 | DIHYDROSPINGOSINE | — | 1 | 5.46 |
| CHEMBL4561149 | — | — | 1 | 5.44 |
| CHEMBL67166 | SPHINGOSINE | — | 1 | 5.44 |
| CHEMBL4460092 | — | — | 1 | 5.41 |
| CHEMBL4447307 | — | — | 1 | 5.29 |
| CHEMBL4452085 | — | — | 1 | 5.26 |
| CHEMBL4563196 | — | — | 1 | 5.24 |
| CHEMBL4537389 | — | — | 1 | 5.24 |
| CHEMBL4537682 | — | — | 1 | 5.14 |
| CHEMBL4565060 | — | — | 1 | 5.00 |
| CHEMBL4473025 | — | — | 1 | 4.98 |
| CHEMBL4549447 | — | — | 1 | 4.85 |
| CHEMBL4470217 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322333 | DIMETHYLSPINGOSINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4467146 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4549134 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4439872 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4440140 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4438374 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4554223 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2441554 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4520668 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4529441 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4579003 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4517011 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4548392 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4455831 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2441555 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4533650 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL448741 | DIHYDROSPINGOSINE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4561149 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL67166 | SPHINGOSINE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4460092 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4447307 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4452085 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4563196 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4537389 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4537682 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4565060 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4473025 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4549447 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL4470217 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4467484 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL105867 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4454274 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL4457876 | — | IC50 | = | 46200.0 | nM | 4.33 |