Assay Detail
Functional
CHEMBL4429336
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Antiparasitic activity against bloodstream form of Trypanosoma brucei 221 infected in mouse VSMC assessed as reduction in parasitic proliferation after 48 hrs by cell titer-glo based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.56 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.10 |
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 6.96 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 6.92 |
| CHEMBL1774055 | — | — | 1 | 6.92 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 6.68 |
| CHEMBL4289017 | PF-03814735 | 1.0 | 1 | 6.58 |
| CHEMBL7064 | — | — | 1 | 6.24 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 6.21 |
| CHEMBL3218578 | BGT-226 FREE BASE | 2.0 | 1 | 6.02 |
| CHEMBL1765602 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1236962 | OMIPALISIB | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1774055 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4289017 | PF-03814735 | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL7064 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL564829 | MILCICLIB | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3218578 | BGT-226 FREE BASE | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1765602 | — | IC50 | = | 1000.0 | nM | 6.00 |