Assay Detail
Functional
CHEMBL4429353
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Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.03 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4526356 | ZB-716 | 1.0 | 1 | 7.43 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 7.38 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4526356 | ZB-716 | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 540.0 | nM | 6.27 |