Assay Detail
Binding
CHEMBL4433103
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Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by liquid scintillation counting method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploration of substituted arylpiperazine-tetrazoles as promising dual norepinephrine and dopamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201066 | VENLAFAXINE HYDROCHLORIDE | 4.0 | 1 | 6.70 |
| CHEMBL4449806 | — | — | 1 | - |
| CHEMBL4557158 | — | — | 1 | - |
| CHEMBL4438467 | — | — | 1 | - |
| CHEMBL4554733 | — | — | 1 | - |
| CHEMBL4452169 | — | — | 1 | - |
| CHEMBL4469505 | — | — | 1 | - |
| CHEMBL4435098 | — | — | 1 | - |
| CHEMBL4579759 | — | — | 1 | - |
| CHEMBL4452761 | — | — | 1 | - |
| CHEMBL4456619 | — | — | 1 | - |
| CHEMBL4539630 | — | — | 1 | - |
| CHEMBL4472139 | — | — | 1 | - |
| CHEMBL4455798 | — | — | 1 | - |
| CHEMBL4441014 | — | — | 1 | - |
| CHEMBL4530231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201066 | VENLAFAXINE HYDROCHLORIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4449806 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4557158 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4554733 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4452169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4469505 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4435098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4579759 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4452761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4456619 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4539630 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4472139 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455798 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4441014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4530231 | — | IC50 | > | 10000.0 | nM | - |