Assay Detail
Functional
CHEMBL4433746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei bloodstream form after 72 hrs by resazurin dye-based assay relative to control
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-<i>Trypanosoma brucei</i> Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.97 | 6.52 |
| IC50 | 1 | 8.81 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.81 |
| CHEMBL4454558 | — | — | 1 | 6.52 |
| CHEMBL4450031 | — | — | 1 | 6.40 |
| CHEMBL4438593 | — | — | 1 | 6.40 |
| CHEMBL4587075 | — | — | 1 | 6.30 |
| CHEMBL4438244 | — | — | 1 | 6.30 |
| CHEMBL4472620 | — | — | 1 | 6.22 |
| CHEMBL4436174 | — | — | 1 | 5.96 |
| CHEMBL4474158 | — | — | 1 | 5.62 |
| CHEMBL1523114 | — | — | 1 | 5.54 |
| CHEMBL4438557 | — | — | 1 | 5.51 |
| CHEMBL4460239 | — | — | 1 | 5.42 |
| CHEMBL4585927 | — | — | 1 | 5.39 |
| CHEMBL4571788 | — | — | 1 | - |
| CHEMBL4585618 | — | — | 1 | - |
| CHEMBL4455272 | — | — | 1 | - |
| CHEMBL4446341 | — | — | 1 | - |
| CHEMBL4476298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL4454558 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4450031 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4438593 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4587075 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4438244 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4472620 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4436174 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4474158 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1523114 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4438557 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4460239 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4585927 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4571788 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4585618 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4455272 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4446341 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4476298 | — | EC50 | > | 10000.0 | nM | - |