Assay Detail
Binding
CHEMBL4434552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein tyrosine phosphatase type IVA 3 (CHEMBL4162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.49 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471843 | — | — | 1 | 7.52 |
| CHEMBL4445621 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471843 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4445621 | — | IC50 | = | 35.0 | nM | 7.46 |