Assay Detail
Binding
CHEMBL4477103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
beta-arrestin effectors and compositions and methods of use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 81 | 6.65 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77838 | — | — | 1 | 8.47 |
| CHEMBL2028943 | — | — | 1 | 8.10 |
| CHEMBL4544902 | — | — | 1 | 8.10 |
| CHEMBL312754 | — | — | 1 | 8.04 |
| CHEMBL4546799 | — | — | 1 | 8.04 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 8.01 |
| CHEMBL4483576 | — | — | 1 | 8.00 |
| CHEMBL938 | SARALASIN | 4.0 | 1 | 7.96 |
| CHEMBL4518530 | — | — | 1 | 7.92 |
| CHEMBL4514079 | — | — | 1 | 7.89 |
| CHEMBL4297447 | TRV-120027 | 2.0 | 1 | 7.77 |
| CHEMBL4567667 | — | — | 1 | 7.70 |
| CHEMBL2392353 | ANGIOTENSIN-II | — | 1 | 7.68 |
| CHEMBL4591448 | — | — | 1 | 7.60 |
| CHEMBL4533618 | — | — | 1 | 7.60 |
| CHEMBL4560224 | — | — | 1 | 7.52 |
| CHEMBL4564950 | — | — | 1 | 7.51 |
| CHEMBL4591857 | — | — | 1 | 7.50 |
| CHEMBL4549405 | — | — | 1 | 7.48 |
| CHEMBL4515848 | — | — | 1 | 7.41 |
| CHEMBL4536886 | — | — | 1 | 7.40 |
| CHEMBL4577691 | — | — | 1 | 7.38 |
| CHEMBL4438122 | — | — | 1 | 7.36 |
| CHEMBL4535997 | — | — | 1 | 7.30 |
| CHEMBL4564617 | — | — | 1 | 7.20 |
| CHEMBL4577270 | — | — | 1 | 7.12 |
| CHEMBL4562270 | — | — | 1 | 7.10 |
| CHEMBL4593310 | — | — | 1 | 7.02 |
| CHEMBL4518318 | — | — | 1 | 7.00 |
| CHEMBL4535678 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77838 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2028943 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4544902 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL312754 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4546799 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL408403 | ANGIOTENSIN II | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4483576 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL938 | SARALASIN | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4518530 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4514079 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4297447 | TRV-120027 | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4567667 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2392353 | ANGIOTENSIN-II | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4533618 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4591448 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4560224 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4564950 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4591857 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4549405 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4515848 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4536886 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4577691 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4438122 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4535997 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4564617 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4577270 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4562270 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4593310 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4518318 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4535678 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4573250 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4518420 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4542709 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4555119 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4588946 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4577692 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4547423 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4522246 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4529051 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4516768 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4579604 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4515768 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4557984 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4543860 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4517561 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4545153 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4551431 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4588454 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4545399 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4590589 | — | EC50 | = | 630.0 | nM | 6.20 |