Compound Detail
CHEMBL2028943
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CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL2028943 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | LFQDNOCWRVJOFJ-LNEAKYCGSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1018.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-1 angiotensin II receptor CHEMBL227 | EC50 | 8.1 | 7.45 | 8.0 | 2 |
| Type-1 angiotensin II receptor A CHEMBL329 | EC50 | 7.85 | 7.675 | 14.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | EC50 | = | 8.0 | nM | 8.1 | Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins b... | - |
| Type-1 angiotensin II receptor A | EC50 | = | 14.0 | nM | 7.85 | Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by... | - |
| Type-1 angiotensin II receptor A | EC50 | = | 32.0 | nM | 7.5 | Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by... | - |
| Type-1 angiotensin II receptor | EC50 | = | 160.0 | nM | 6.8 | Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins b... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2913307 | 10.1021/jm00122a030 | Rattus norvegicus | 2 |
| 2913307 | 10.1021/jm00122a030 | Type-2 angiotensin II receptor | 1 |
| 2913307 | 10.1021/jm00122a030 | Oryctolagus cuniculus | 1 |
Data from ChEMBL 36 via Core Engine