Assay Detail
Functional
CHEMBL4477109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor A (CHEMBL329) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
beta-arrestin effectors and compositions and methods of use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 80 | 7.08 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 8.89 |
| CHEMBL77838 | — | — | 1 | 8.46 |
| CHEMBL938 | SARALASIN | 4.0 | 1 | 8.22 |
| CHEMBL312754 | — | — | 1 | 8.18 |
| CHEMBL4588946 | — | — | 1 | 8.17 |
| CHEMBL2392353 | ANGIOTENSIN-II | — | 1 | 8.14 |
| CHEMBL4545153 | — | — | 1 | 8.13 |
| CHEMBL4515848 | — | — | 1 | 8.09 |
| CHEMBL4438122 | — | — | 1 | 7.96 |
| CHEMBL4518530 | — | — | 1 | 7.92 |
| CHEMBL4518318 | — | — | 1 | 7.89 |
| CHEMBL4588454 | — | — | 1 | 7.70 |
| CHEMBL4562270 | — | — | 1 | 7.62 |
| CHEMBL4560224 | — | — | 1 | 7.58 |
| CHEMBL2028943 | — | — | 1 | 7.50 |
| CHEMBL4555119 | — | — | 1 | 7.46 |
| CHEMBL4517561 | — | — | 1 | 7.39 |
| CHEMBL4559239 | — | — | 1 | 7.23 |
| CHEMBL4567667 | — | — | 1 | 7.19 |
| CHEMBL4516066 | — | — | 1 | 7.11 |
| CHEMBL4515768 | — | — | 1 | 7.10 |
| CHEMBL2370909 | — | — | 1 | 7.04 |
| CHEMBL4544308 | — | — | 1 | 7.02 |
| CHEMBL4572408 | — | — | 1 | 7.00 |
| CHEMBL4554466 | — | — | 1 | 6.70 |
| CHEMBL4573250 | — | — | 1 | 6.66 |
| CHEMBL4551317 | — | — | 1 | 6.62 |
| CHEMBL4547423 | — | — | 1 | 6.60 |
| CHEMBL4544228 | — | — | 1 | 6.58 |
| CHEMBL4522038 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL77838 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL938 | SARALASIN | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL312754 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4588946 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2392353 | ANGIOTENSIN-II | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4545153 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4515848 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4438122 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4518530 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4518318 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4588454 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4562270 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4560224 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2028943 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4555119 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4517561 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4559239 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4567667 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4516066 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4515768 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2370909 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4544308 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4572408 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4554466 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4573250 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4551317 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4547423 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4544228 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4522038 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4543860 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4581718 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4561366 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4516768 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4559421 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4576650 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4583284 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4533618 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4483576 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4535997 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4571382 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4577692 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4564617 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4557984 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4518420 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4514079 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4535678 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4524570 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4549405 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4590381 | — | EC50 | > | 10000.0 | nM | - |