Assay Detail
Binding
CHEMBL4478049
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Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.22 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4549208 | — | — | 1 | 6.54 |
| CHEMBL3787713 | — | — | 1 | 6.44 |
| CHEMBL4522438 | — | — | 1 | 6.40 |
| CHEMBL3787712 | — | — | 1 | 6.39 |
| CHEMBL4456247 | — | — | 1 | 6.36 |
| CHEMBL3787766 | — | — | 1 | 6.14 |
| CHEMBL4475071 | — | — | 1 | 6.03 |
| CHEMBL4581256 | — | — | 1 | 5.85 |
| CHEMBL4533775 | — | — | 1 | 5.80 |
| CHEMBL4576579 | — | — | 1 | - |
| CHEMBL4581302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4549208 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3787713 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4522438 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3787712 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL4456247 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3787766 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL4475071 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL4581256 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4533775 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4576579 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL4581302 | — | Ki | > | 10000.0 | nM | - |