Assay Detail
Binding
CHEMBL4478055
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Displacement of [3H]propionyl-pNPY from human NPY Y5 receptor expressed in human HEC1b cells after 120 mins by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.34 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787712 | — | — | 1 | 6.85 |
| CHEMBL3787713 | — | — | 1 | 6.66 |
| CHEMBL4581256 | — | — | 1 | 6.66 |
| CHEMBL3787766 | — | — | 1 | 6.55 |
| CHEMBL4549208 | — | — | 1 | 6.40 |
| CHEMBL4533775 | — | — | 1 | 6.34 |
| CHEMBL4576579 | — | — | 1 | 6.26 |
| CHEMBL4522438 | — | — | 1 | 6.15 |
| CHEMBL4456247 | — | — | 1 | 5.82 |
| CHEMBL4475071 | — | — | 1 | 5.68 |
| CHEMBL4581302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787712 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3787713 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4581256 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3787766 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL4549208 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL4533775 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL4576579 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL4522438 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL4456247 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4475071 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL4581302 | — | Ki | > | 10000.0 | nM | - |