Assay Detail
Binding
CHEMBL4478192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PI3Kbeta using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent based luminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.07 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4565988 | — | — | 1 | 7.68 |
| CHEMBL222102 | KU-55933 | — | 1 | 6.88 |
| CHEMBL4527822 | — | — | 1 | 6.86 |
| CHEMBL2140173 | — | — | 1 | 5.67 |
| CHEMBL2143829 | — | — | 1 | 5.26 |
| CHEMBL4593348 | — | — | 1 | 5.24 |
| CHEMBL4166405 | — | — | 1 | 4.89 |
| CHEMBL4218734 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4565988 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL222102 | KU-55933 | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4527822 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2140173 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL2143829 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL4593348 | — | IC50 | = | 5740.0 | nM | 5.24 |
| CHEMBL4166405 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4218734 | — | IC50 | > | 27000.0 | nM | - |