Assay Detail
Functional
CHEMBL4478537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of pan Pim in SCID-bg mouse xenografted with human KMS-12-BM cells assessed as plasma concentration required for reduction of BAD peptide phosphorylation at Serine 112 residue at 10 to 100 mg/kg, po qd measured after 1 to 24 hrs post dose
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.59 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3979678 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3979678 | — | EC50 | = | 254.0 | nM | 6.59 |