Assay Detail
Functional
CHEMBL4479167
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Antiviral activity against HIV1 infected in human PBMC assessed as inhibition of viral replication by measuring reverse transcriptase activity in cell supernatant preincubated with cells followed by viral infection measured after 7 days by radioactive incorporation polymerization assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 7.12 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4591641 | — | — | 1 | 9.30 |
| CHEMBL4559882 | — | — | 1 | 9.22 |
| CHEMBL4574633 | — | — | 1 | 9.19 |
| CHEMBL4522332 | — | — | 1 | 8.52 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 8.34 |
| CHEMBL4526488 | — | — | 1 | 8.30 |
| CHEMBL4530614 | — | — | 1 | 7.75 |
| CHEMBL515564 | TENOFOVIR EXALIDEX | 2.0 | 1 | 7.70 |
| CHEMBL4581747 | — | — | 1 | 7.58 |
| CHEMBL4540957 | — | — | 1 | 7.31 |
| CHEMBL4535399 | — | — | 1 | 7.07 |
| CHEMBL4547349 | — | — | 1 | 6.85 |
| CHEMBL4583653 | — | — | 1 | 6.72 |
| CHEMBL4582521 | — | — | 1 | 6.72 |
| CHEMBL4532461 | — | — | 1 | 6.67 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.50 |
| CHEMBL4529939 | — | — | 1 | 6.48 |
| CHEMBL4558053 | — | — | 1 | 6.46 |
| CHEMBL4536590 | — | — | 1 | 6.46 |
| CHEMBL4581778 | — | — | 1 | 6.04 |
| CHEMBL4572472 | — | — | 1 | 5.93 |
| CHEMBL4590974 | — | — | 1 | 5.79 |
| CHEMBL4578738 | — | — | 1 | 5.20 |
| CHEMBL4557355 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4591641 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4559882 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4574633 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL4522332 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4526488 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4530614 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL515564 | TENOFOVIR EXALIDEX | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4581747 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4540957 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4535399 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4547349 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4583653 | — | EC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4582521 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4532461 | — | EC50 | = | 216.0 | nM | 6.67 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 319.0 | nM | 6.50 |
| CHEMBL4529939 | — | EC50 | = | 331.0 | nM | 6.48 |
| CHEMBL4558053 | — | EC50 | = | 349.0 | nM | 6.46 |
| CHEMBL4536590 | — | EC50 | = | 349.0 | nM | 6.46 |
| CHEMBL4581778 | — | EC50 | = | 911.0 | nM | 6.04 |
| CHEMBL4572472 | — | EC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL4590974 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4578738 | — | EC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL4557355 | — | EC50 | = | 18600.0 | nM | 4.73 |