Assay Detail
Binding
CHEMBL4479286
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Inhibition of equine serum BuChE preincubated for 6 mins followed by addition of S-butyrylthiocholine iodide by Ellman's method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.24 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.79 |
| CHEMBL4541730 | — | — | 1 | 4.46 |
| CHEMBL4536296 | — | — | 1 | 4.46 |
| CHEMBL4531267 | — | — | 1 | 4.44 |
| CHEMBL4524162 | — | — | 1 | 4.39 |
| CHEMBL4578074 | — | — | 1 | 4.36 |
| CHEMBL4584351 | — | — | 1 | 4.34 |
| CHEMBL4522818 | — | — | 1 | 4.34 |
| CHEMBL4581887 | — | — | 1 | 4.34 |
| CHEMBL4571408 | — | — | 1 | 4.33 |
| CHEMBL4545234 | — | — | 1 | 4.29 |
| CHEMBL4547644 | — | — | 1 | 4.25 |
| CHEMBL4521556 | — | — | 1 | 4.22 |
| CHEMBL4516485 | — | — | 1 | 4.22 |
| CHEMBL4561751 | — | — | 1 | 4.22 |
| CHEMBL4572737 | — | — | 1 | 4.21 |
| CHEMBL4539017 | — | — | 1 | 4.17 |
| CHEMBL4534953 | — | — | 1 | 4.17 |
| CHEMBL4525497 | — | — | 1 | 4.16 |
| CHEMBL4576458 | — | — | 1 | 4.15 |
| CHEMBL4549496 | — | — | 1 | 4.14 |
| CHEMBL4530986 | — | — | 1 | 4.11 |
| CHEMBL4515828 | — | — | 1 | 4.08 |
| CHEMBL4513605 | — | — | 1 | 4.05 |
| CHEMBL4589486 | — | — | 1 | 4.04 |
| CHEMBL4581664 | — | — | 1 | 4.04 |
| CHEMBL4551175 | — | — | 1 | 4.03 |
| CHEMBL4525580 | — | — | 1 | 4.02 |
| CHEMBL4540499 | — | — | 1 | - |
| CHEMBL4513836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 16320.0 | nM | 4.79 |
| CHEMBL4541730 | — | IC50 | = | 34450.0 | nM | 4.46 |
| CHEMBL4536296 | — | IC50 | = | 34780.0 | nM | 4.46 |
| CHEMBL4531267 | — | IC50 | = | 36250.0 | nM | 4.44 |
| CHEMBL4524162 | — | IC50 | = | 40340.0 | nM | 4.39 |
| CHEMBL4578074 | — | IC50 | = | 43660.0 | nM | 4.36 |
| CHEMBL4584351 | — | IC50 | = | 45150.0 | nM | 4.34 |
| CHEMBL4522818 | — | IC50 | = | 45520.0 | nM | 4.34 |
| CHEMBL4581887 | — | IC50 | = | 45560.0 | nM | 4.34 |
| CHEMBL4571408 | — | IC50 | = | 47230.0 | nM | 4.33 |
| CHEMBL4545234 | — | IC50 | = | 50760.0 | nM | 4.29 |
| CHEMBL4547644 | — | IC50 | = | 56230.0 | nM | 4.25 |
| CHEMBL4521556 | — | IC50 | = | 60230.0 | nM | 4.22 |
| CHEMBL4516485 | — | IC50 | = | 60780.0 | nM | 4.22 |
| CHEMBL4561751 | — | IC50 | = | 60460.0 | nM | 4.22 |
| CHEMBL4572737 | — | IC50 | = | 60960.0 | nM | 4.21 |
| CHEMBL4539017 | — | IC50 | = | 67770.0 | nM | 4.17 |
| CHEMBL4534953 | — | IC50 | = | 68120.0 | nM | 4.17 |
| CHEMBL4525497 | — | IC50 | = | 68950.0 | nM | 4.16 |
| CHEMBL4576458 | — | IC50 | = | 70760.0 | nM | 4.15 |
| CHEMBL4549496 | — | IC50 | = | 72850.0 | nM | 4.14 |
| CHEMBL4530986 | — | IC50 | = | 78560.0 | nM | 4.11 |
| CHEMBL4515828 | — | IC50 | = | 83120.0 | nM | 4.08 |
| CHEMBL4513605 | — | IC50 | = | 89560.0 | nM | 4.05 |
| CHEMBL4589486 | — | IC50 | = | 90860.0 | nM | 4.04 |
| CHEMBL4581664 | — | IC50 | = | 90760.0 | nM | 4.04 |
| CHEMBL4551175 | — | IC50 | = | 92830.0 | nM | 4.03 |
| CHEMBL4525580 | — | IC50 | = | 95450.0 | nM | 4.02 |
| CHEMBL4540499 | — | IC50 | - | — | - | |
| CHEMBL4513836 | — | IC50 | - | — | - |